ʻO ka mea hoʻoponopono wai hoʻokō kiʻekiʻe (HPLC) kahi ʻano o ka pae kelepona e hoʻohana ana i ka wai e like me ka pae paʻa. Lawe ʻia ka hāpana a me ka mea hoʻoheheʻe i ke kolamu chromatographic i hoʻopiha ʻia me ka pae paʻa ma o ka pauma kiʻekiʻe. E like me nā pūʻali like ʻole ma waena o nā ʻāpana like ʻole i ka hāpana a me ka pae paʻa, nā ʻenehana Chromatic no ka hoʻokaʻawale ʻana, qualitative a quantitative analysis of samples. Loaʻa iā ia nā pōmaikaʻi o ka hoʻokaʻawale ʻana kiʻekiʻe, ka wikiwiki o ka nānā ʻana, ka naʻau kiʻekiʻe a me ka reproducibility maikaʻi, a hoʻohana nui ʻia i ka kemika organik, biochemistry, lāʻau lapaʻau, meaʻai, kaiapuni a me nā māla ʻē aʻe.